Hyperkalemia Market Hots Up In EU with Okay for AZ's Lokelma

Rival Vifor Pharma has predicted blockbuster status for Veltassa and AstraZeneca expects the same for its just-approved oral potassium-removing agent, hoping that Lokelma's faster onset of action will help it win the fight for market share in hyperkalemia.

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Lokelma OK lights the fire for competition in hyperkalemia • Source: Shutterstock

It has taken longer than expected but AstraZeneca PLC has now received European approval for Lokelma (sodium zirconium cyclosilicate), which will go head-to-head in the hyperkalemia space with Vifor Pharma Group's Veltassa (patiromer).

The European Commission's green light for Lokelma, previously known as ZS-9, comes two months after the EMA's Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion of the drug for the treatment of adults with hyperkalemia, a condition characterized by elevated potassium levels in the blood associated with cardiovascular, renal and metabolic diseases

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