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Novo's Oral Semaglutide Passes PIONEER 2, But Weight Loss Result A Bit Disappointing

 
• By Emily Hayes

In second Phase III diabetes study to report, oral GLP-1 agonist semaglutide misses some weight loss goals when compared with Boehringer/Lilly's SGLT-2 inhibitor Jardiance.

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Novo Nordisk AS's once-daily, oral version of the GLP-1 agonist semaglutide demonstrated superior blood sugar lowering in the Phase III PIONEER 2 study, which tested the drug against Eli Lilly & Co./Boehringer Ingelheim GMBH's SGLT-2 inhibitor Jardiance (empagliflozin), while falling a bit short on weight loss and carrying nausea as a common side effect.

The Phase III PIONEER program includes 10 studies in type 2 diabetes and Novo plans to report results from all of them this year, potentially paving the way for an oral semaglutide filing in 2019 and launch in 2020 (see graphic). The company announced positive results from the PIONEER 2 study, the second pivotal trial, on May 29, following a positive release for PIONEER 1 in February. (Also see "Novo Nordisk's Oral Semaglutide Succeeds In First Phase III, But Prompts Questions" - Scrip, 23 February, 2018

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