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Eisai/Biogen Remain In BACE Race As Alzheimer's Contenders Dwindle

 
• By Mandy Jackson

Multiple competitors have ended development of BACE inhibitors for the treatment of Alzheimer's disease, but Eisai neurology executive Lynn Kramer tells Scrip that the company still sees a path forward for certain amyloid-targeting drugs.

MR image of Human brain

Eisai Co. Ltd. and Biogen reported 18-month top-line results from a Phase II study of elenbecestat in Alzheimer's patients with mild cognitive impairment (MCI) or mild-to-moderate dementia on June 5 that they believe support the decision to move into Phase III despite multiple failures for competing BACE inhibitors.

Scrip spoke with Lynn Kramer, chief clinical officer and chief medical officer of Eisai's neurology business group, about results from Study 202 for elenbecestat, the partners' second most advanced amyloid-targeting drug candidate, after aducanumab

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