Lilly Stays Committed To Alzheimer's, Including Amyloid Hypothesis, Despite Many Failures

The failure of BACE inhibitor lanabecestat was the latest setback in Lilly's Alzheimer's pipeline, but the company has been working in this area with almost no success for decades, yet still feels a commitment to keep trying, Lilly Research Labs President Daniel Skovronsky tells Scrip.

Sand running through the bulbs of an hourglass measuring the passing time in a countdown to a deadline, on a dark background with copy space.

Eli Lilly & Co. has not given up hope of finding a disease-modifying treatment for Alzheimer's disease, despite many failed attempts, including the recently discontinued Phase III program for the beta secretase cleaving enzyme (BACE) inhibitor lanabecestat.

In fact, Lilly Research Labs President Daniel Skovronsky said in an interview on June 13 – the day after the company and partner AstraZeneca PLC announced the lanabecestat failure –

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