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Siga Ready For Next Phase, New Cash With Smallpox Drug Approval

 
• By Sue Sutter

Siga is entitled to a $41m “hold back” payment under its contract with the Biomedical Advanced Research and Development Authority and potentially a $50m payment related to the US FDA's extended shelf-life determination for stockpiled Tpoxx; company also picks up first priority review voucher awarded for a medical countermeasure, which it likely will monetize.

Variola virus, a virus from Orthopoxviridae family that causes smallpox, highly contagious disease eradicated by vaccination, 3D illustration
Tpoxx becomes the first drug approved to treat smallpox, which is caused by the variola virus.

With the US FDA approval of the smallpox drug Tpoxx (tecovirimat) now behind it, Siga Technologies Inc. is looking forward to an influx of as much as $91m, plus the proceeds from a priority review voucher sale, to help expand the drug’s indications and add new pipeline assets consistent with the company’s health security focus.

The FDA approved tecovirimat, an oral inhibitor of the orthopoxvirus VP37 envelope wrapping protein, on July 13 for the treatment of human

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