Not To Be Sniffed At: Dupixent Success In Rhinosinusitis Could Open Up Large Additional Market

On the brink of an expanded US approval for asthma, Sanofi/Regeneron’s interleukin-4 receptor blocker Dupixent has produced positive topline Phase III data in a lucrative third indication, rhinosinusitis with nasal polyps.

Tissues

Sanofi and Regeneron Pharmaceuticals Inc. look set to exploit a third indication for their monoclonal antibody product, Dupixent (dupilumab), after the product hit its co-primary and all secondary endpoints in two Phase III trials in patients with adults with inadequately controlled chronic rhinosinusitis with nasal polyps (CRSwNP).

The data come as the companies await an US FDA decision on the approval of Dupixent in its second indication,...

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