Clinical development failures in major depressive disorder (MDD) are nothing new, but Allergan PLC’s trio of unsuccessful Phase III studies with NMDA receptor modulator rapastinel might be more damaging because of the company’s recent litany of R&D setbacks, along with Johnson & Johnson’s US approval in the same class with Spravato on March 5.
Allergan announced top-line results late in the day March 6 showing that rapastinel – a driver of its $560m purchase...
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