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AbbVie’s Post-Humira Strategy Continues Taking Shape With Rinvoq Approval

 
• By Joseph Haas and Mary Jo Laffler

AbbVie now has both of its Humira successors approved in the US, following April’s Skyrizi approval for psoriasis. But Rinvoq faces stiff competition both within the JAK1 class and in rheumatoid arthritis generally.

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Rinvoq is approved to treat moderate to severe rheumatoid arthritis. • Source: Shutterstock

AbbVie Inc. obtained its second approval in 2019 of an autoimmune therapy intended to help replace revenue from biosimilar-threatened Humira, as the US Food and Drug Administration okayed Rinvoq (upadacitinib) on 16 August to treat patients with moderately to severely active rheumatoid arthritis who have had inadequate responses to or cannot tolerate methotrexate.

The Chicago-area pharma is reportedly pricing the once-daily oral Janus kinase 1 (JAK1) inhibitor at $59,000 a year, and it

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