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Enanta Stumbles In Trying To Show Better FXR Agonist Profile In NASH

 
• By Joseph Haas

Enanta hoped its Phase II study would indicate a better efficacy and/or tolerability profile for EDP-305 compared to other FXR agonists for NASH, including Intercept’s OCA. Despite the inconclusive data, it plans a longer Phase IIb study.

Blood sample with requisition form for liver enzyme (AST, ALT) test - Image
Enanta's NASH drug lowered ALT levels, but the fuller picture is unclear

Enanta Pharmaceuticals Inc. is one of at least six companies working to develop a farnesoid X receptor (FXR) agonist for non-alcoholic steatohepatitis that might offer a better overall risk/benefit profile than Intercept Pharmaceuticals Inc.’s obeticholic acid (OCA) – likely to be the first drug approved for NASH – but data from its Phase IIa ARGON-1 study don’t offer a conclusive case on efficacy or tolerability.

The Boston-based infectious disease specialist unveiled data on 25 September testing 2.5mg and 1mg doses of EDP-305 in NASH patients...

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