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Amgen KRAS Inhibitor Less Effective In Colorectal Cancer Than Lung

 
• By Mandy Jackson

New data for AMG 510 at ESMO show the drug is more active in lung than colorectal cancer, as was reported at ASCO, but Amgen's Greg Friberg notes that Phase I monotherapy and planned combination studies may shed more light on KRAS biology and efficacy in different tumor types.

Colon cancer. Cancer attacking cells. Colon disease concept. 3d illustration - Illustration
One of 12 colorectal cancer patients had a partial response to AMG 510. • Source: Shutterstock

Updated results for Amgen Inc.'s AMG 510, its small molecule targeting the G12C mutation of the KRAS oncogene, that were presented at the European Society for Medical Oncology (ESMO) meeting on 28 September in Barcelona, Spain, showed limited efficacy in colorectal cancer (CRC) patients, but the company is optimistic that its drug can perform better than approved CRC therapies, particularly in combination with other agents.

Only one out of 12 colorectal cancer patients (8%) treated with 960mg of AMG 510 daily – the highest dose tested and the dose being studied in further trials – achieved a partial response as of data collected through 17 July in an ongoing Phase I dose expansion study

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