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Deciphera's Ripretinib Cuts GIST Death Risk By 64%; US Filing On Track For Early 2020

 
• By Leah Samuel

Overall survival for patients with gastrointestinal stromal tumors (GIST) in the fourth-line setting was 15.1 months versus 6.6 months for placebo, building on impressive progression-free survival results.

Digital illustration of Cancer cell in colour background
Deciphera encouraged by overall survival data

An encouraging improvement in overall survival in the Phase III INVICTUS clinical trial for Deciphera Pharmaceuticals Inc.'s ripretinib build on previously reported progression-free survival data and keep the company on track to seek US Food and Drug Administration approval in early 2020 for its kinase inhibitor in the fourth-line treatment of gastrointestinal stromal tumors (GIST).

Data presented at the European Society for Medical Oncology (ESMO) Congress on 30 September in Barcelona showed median overall survival of 15.1 months for heavily pre-treated GIST patients in the ripretinib arm of INVICTUS and 6.6 months for those who received placebo, which translated to a 64% reduction in the risk of death (HR=0.36, nominal p=0.0004)

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Pipeline Watch: Eight Approvals And Nineteen Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.