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AbbVie’s Venclexta Fails In Combo AML Trial

Pfizer’s Daurismo May Benefit From Venclexta’s VIALE-C Setback

 
• By Sten Stovall

AbbVie’s Venclexta failed to show a significant improvement in the primary endpoint of overall survival in the Phase III VIALE-C for AML, but there was numerical improvement. Its setback is good news for Pfizer’s rival Daurismo, analysts said.

AML
Venclexta missed VIALE-C Phase III endpoints in acute myeloid leukemia • Source: Shutterstock

Prospects for AbbVie Inc.’s Venclexta (venetoclax) becoming a fully approved treatment for acute myeloid leukemia (AML) were thrown into doubt when the B-cell lymphoma-2 inhibitor failed to show a significant improvement in the primary endpoint of overall survival (OS) in the ongoing VIALE-C Phase III study, although it did demonstrate numerical improvement.

AbbVie on 28 February said that the VIALE-C trial evaluating Venclexta in combination with low-dose cytarabine (LDAC) versus LDAC in...

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