Roche’s First Anti-TIGIT Data Support Dual Checkpoint Inhibition Strategy

The first public data disclosure for Roche’s anti-TIGIT antibody tiragolumab in combination with the company’s PD-L1 inhibitor Tecentriq (atezolizumab) in first-line metastatic non-small cell lung cancer (NSCLC) showed improved response rates versus Tecentriq alone – including a notable improvement in high PD-L1-expressing tumors – and without adding significant toxicity.

The dual checkpoint inhibitor strategy could give Roche’s Tecentriq a critical boost in PD-1/L1 market share before competing combinations reach the market, since analysts estimate that other anti-TIGIT antibodies are at least a year behind