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New Pfizer/BioNTech COVID-19 Vaccine Data Confirm Prior Results, Show T-Cell Boost

 
• By Mandy Jackson

While data from small trials are difficult to compare, it appears that T-cell responses to BNT162b1 may be stronger than those reported so far for Moderna’s competing mRNA-based vaccine. 

Vaccination against the new Corona Virus SARS-CoV-2: A syringe being drawn up with SARS-CoV-2 vaccination.
Pfizer and BioNTech report results from a second Phase I/II study, which was conducted in Germany • Source: Shutterstock

Pfizer Inc. and BioNTech SE released Phase I/II results for their messenger RNA (mRNA)-based COVID-19 vaccine candidate BNT162b1, from a clinical trial conducted in Germany, that showed T-cell responses that may be stronger than those observed with a competing mRNA vaccine from Moderna, Inc. The data are also consistent with neutralizing antibody data reported previously from a US study.

Pfizer and BioNTech reported results on 20 July from 60 German trial participants, including 12 patients each injected with 1mcg, 10mcg, 30mcg or 50mcg doses of BNT162b1 on days one and 22, or a single dose on day one of 6mcg

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