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Migraine Market Update: CGRP Inhibitors Slowly Gain Ground

New Medicines For The Condition More Than Doubled This Year

 
• By Mandy Jackson

The market for novel preventive and acute treatments grew from three anti-CGRP antibodies at the start of 2020 to four biologics and two oral drugs against CGRP plus a small molecule 5-HT1F inhibitor. 

Migraine word written on wood block. Migraine text on wooden table for your desing, concept.
Seven migraine drugs have been approved since 2018; four launched this year • Source: Shutterstock

It appears that the COVID-19 pandemic largely has not had a big impact on sales of novel migraine therapies, except for the one new product that can’t be administered by patients at home. In fact, with four new products launched since the beginning of 2020, overall sales of new migraine drugs – preventive therapies or acute treatments – increased 80.5% year-over-year in the second quarter.

Sales of the six calcitonin gene-related peptide (CGRP) inhibitors approved since 2018 totaled $253.3m in Q2 versus $140.3m for the three anti-CGRP antibodies on the market in the second quarter of 2019. (See chart below.) Eli Lilly and Company did not report sales for its serotonin (5-HT) 1F receptor agonist Reyvow (lasmiditan), which launched in January at the same time that Allergan plc (now part of AbbVie Inc.) launched the first-ever oral CGRP inhibitor Ubrelvy (ubrogepant)

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