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BeiGene’s PD-1 Remains Solid In First Global Pivotal Study

Positive Interim Data In Later-Line NSCLC

 
• By Ian Haydock

Tislelizumab meets overall survival endpoint in later-line NSCLC at planned interim analysis, but faces exploding competition in the Chinese immuno-oncology sector.

Doctor examining at lungs radiograph x-ray film of patient in operation room. medical concept.
Another Positive Interim Readout For Tislelizumab • Source: Shutterstock

BeiGene, Ltd.’s tislelizumab has met its overall survival primary endpoint in a Phase III trial for later-line use in non-small cell lung cancer (NSCLC), in what is the first positive global pivotal clinical trial result for the Chinese firm’s anti-PD-1 antibody.

The drug, already approved in China (as Baize'An) for lymphoma and urothelial cancer, is in a broad clinical program, including in several settings in NSCLC, which represents potentially one of...

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In Brief: Neurocrine Details New Data For Schizophrenia Drug Moving To Phase III

 
• By Sushmita Panda

Neurocrine reports new details of positive Phase II results in schizophrenia and a favorable safety and cardiovascular profile for its first-in-class oral M4 agonist, now moving to Phase III trials.

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Merck & Co./Daiichi Pull Patritumab Deruxtecan BLA On Disappointing OS

 
• By Jessica Merrill

Patritumab deruxtecan is the lead antibody drug conjugate in a $22bn deal signed between the two partners, with the decision marking a disappointing setback