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AstraZeneca And Sanofi March Ahead With Positive Phase III RSV Data

MELODY Data Music To Companies’ Ears

 
• By Alexandra Shimmings

AstraZeneca and Sanofi have leapt forward in their plans to shake up the RSV market with earlier than expected positive data for their passive immunization product nirsevimab. Rival maternal vaccines in development will cast a shadow, however.    

lung illustration
• Source: Shutterstock

An earlier than expected and positive read-out of a Phase III trial of AstraZeneca PLC and Sanofi’s nirsevimab puts the firms firmly in prime position to shake up the substantial and as yet mostly untapped respiratory syncytial virus (RSV) market.

Top-line data from the MELODY study show that the passive immunotherapy met its primary endpoint of a reduction in the incidence of medically attended lower respiratory tract infections (LRTI) caused by RSV through 150 days after a single dose compared with placebo in healthy late preterm and term infants (35 weeks or more)

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