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Adverum Halts Phase II Gene Therapy Trial After Patient’s Vision Loss

 
• By Joseph Haas

Slated to begin a Phase III later this year of ADVM-022 in wet AMD, Adverum had to scuttle a Phase II study of the gene therapy in DME after a patient suffered ocular hypotension, panuveitis and vision loss in the treated eye.

Adverum's significant adverse event is the latest setback in gene therapy development

The timing of a planned Phase III of Adverum Biotechnologies, Inc.’s gene therapy ADVM-022 in wet age-related macular edema (AMD) is in doubt after the company revealed on 28 April that it halted a Phase II study of ADVM-022 in diabetic macular edema (DME) following one patient losing vision in one eye.

The AMD trial was slated to begin in late 2021.

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