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Anti-CD20 Bispecifics Could Find Niche In First-Line Lymphoma

Highly Entrenched Rituxan Could Prove Tough To Dislodge

 
• By Alaric DeArment

Roche presented data at ASCO on its two CD20-targeting bispecific antibodies, showing high response rates in heavily pretreated non-Hodgkin lymphoma patients.

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Roche presented data at ASCO on its two CD20xCD3-targeting bispecific antibodies • Source: Shutterstock

With high response rates in heavily pretreated non-Hodgkin’s lymphoma (NHL) patients, Roche Holding AG hopes to eventually move its CD20-targeting bispecific antibodies mosunetuzumab and glofitamab into earlier lines of therapy, where they could potentially replace long-established anti-CD20 monoclonal antibody players like its own Rituxan (rituximab) and Gazyva (obinutuzumab). But it’s more likely that the bispecifics will fit into certain niches of diffuse large B-cell lymphoma (DLBCL) patients who do not respond well to Rituxan/chemotherapy approaches.

Rituxan has long been a dominant force in NHL and similar cancers and will be a hard drug to unseat, but it now faces pressure from biosimilars. (Also see "

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More from ASCO

ASCO: Trodelvy First-Line TNBC Data Seen As Potentially Practice-Changing

 
• By Alaric DeArment

Gilead chief medical officer Dietmar Berger said in an interview that the company plans to quickly take the results to regulators and foresees broad first-line use of the drug.

ASCO: Merck’s Zilo-V Shows Activity, But Numbers Still Small

 
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ASCO Preview: Major Solid Tumor Readouts Include AstraZeneca/Daiichi, Gilead ADCs

 
• By Alaric DeArment

Data from several closely watched solid tumor drug trials – some considered practice-changing – are scheduled for presentation at the meeting, including for AstraZeneca and Daiichi’s Enhertu.

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ASCO Preview: Major Solid Tumor Readouts Include AstraZeneca/Daiichi, Gilead ADCs

 
• By Alaric DeArment

Data from several closely watched solid tumor drug trials – some considered practice-changing – are scheduled for presentation at the meeting, including for AstraZeneca and Daiichi’s Enhertu.

ASCO Preview: Data From Regeneron, J&J/Legend And Others In Hematology

 
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With the American Society of Clinical Oncology meeting kicking off on 30 May, Scrip will follow the latest in blood cancers, including Regeneron’s linvoseltamab in multiple myeloma and Merck’s ADC zilovertamab vedotin in DLBCL.

Merus Bispecific Impresses In Head And Neck Cancer

 
• By Andrew McConaghie

Updated Phase II results from petosemtamab have impressed ahead of ASCO, outshining Keytruda monotherapy and its bispecific rival from Bicara.