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Bone Has Tough Path Forward After Phase III Knee Osteoarthritis Fail

 
• By Alaric DeArment

The company said the study of JTA-004 failed to meet its primary and key secondary endpoints, though a post-hoc analysis indicated activity in a patient subset.

Film x-ray knee joint with arthritis
• Source: Shutterstock

Bone Therapeutics SA may find itself with limited options for its lead product candidate, JTA-004, following the failure of its Phase III trial in knee osteoarthritis pain. Although a post-hoc analysis points to potential efficacy of JTA-004 in certain patients, the company is now focusing on ALLOB, which occupies the second place in its pipeline and is being developed for orthopedic indications.

The Belgian biotech said 30 August that in the 746-patient Phase III study JTA-004 did not meet its primary endpoint, which was to reduce osteoarthritic knee pain versus placebo based on the WOMAC pain subscale three months after treatment

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