Five Pivotal Trial Read-Outs To Look Out For In Early 2022

17 Jan 2022

• By Ayisha Sharma

Five notable studies are expected to report top-line data in the first quarter. With the help of Biomedtracker's Early 2022 Outlook Report, we take a look at the major catalysts likely to kick off the year, including in heart failure and wet AMD.

New containers for empty medicines, chemical pharmaceutical industry concept. — The Biomedtracker report looks at upcoming catalysts for drugs that could be lining shelves in future. • Source: Alamy

Cytokinetics, Inc. is expected to release top-line data from the Phase III METEORIC-HF study of omecamtiv mecarbil, a selective cardiac myosin activator, by the end of April. The METEORIC-HF study has enrolled 276 heart failure patients with reduced ejection fraction and decreased exercise tolerance and measures the primary endpoint of change in peak oxygen uptake on cardiopulmonary exercise testing from baseline to week 20.

The development of omecamtiv has been hindered by obstacles, with the candidate showing only a slim efficacy benefit in the...