UCB S.A.’s complement component 5 (C5) inhibitor peptide zilucoplan hit the primary endpoint and two secondary endpoints in a Phase III study in generalized myasthenia gravis (gMG), the firm announced 4 February, helping advance its two-drug strategy for the neuromuscular autoimmune disease. UCB plans regulatory filings in the US, EU and Japan later this year for both zilucoplan and for rozanolixizumab, a neonatal Fc receptor (FcRn)-targeted antibody that met the same primary endpoint in Phase III data reported in 2021.
UCB Advances Two-Drug Strategy For Myasthenia Gravis
Successful Phase III data for UCB’s C5 inhibitor zilucoplan adds to a similarly positive Phase III readout for its rozanolixizumab in December, but details are lacking. UCB is the only company with two mechanisms for MG.
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Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.
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