Sage/Biogen Depression Data Likely To Prolong Commercial Debate

Data from the Phase III CORAL study of zuranolone showed the drug missing efficacy at day 15, which may dampen its appeal in the real-world setting.

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Sage/Biogen announced results from the Phase III CORAL study of zuranolone in major depressive disorder • Source: Shutterstock

Debate over the commercial viability of Sage Therapeutics, Inc./Biogen, Inc.’s zuranolone isn’t getting any quieter as additional data rolls in. The Phase III CORAL study in major depressive disorder (MDD) met its primary endpoint of rapid onset of anti-depressant effect, with an acceptable safety and tolerability profile, but missed a key endpoint on durability.

The companies unveiled the CORAL data on 16 February, saying that the trial met its primary endpoint of a rapid...

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