Long-Term Vitiligo Data Appear To Lay Opzelura Safety Concerns To Rest

Incyte’s topical JAK inhibitor carries a class-wide severe safety warning and cautions against chronic use, but 52-week results could ease the way for the potential vitiligo indication.

Incyte announced updated data for topical JAK inhibitor Opzelura in vitiligo • Source: Alamy

New 52-week Phase III data for Incyte Corporation’s topical JAK inhibitor Opzelura (ruxolitinib) for vitiligo show no new safety signals, despite lingering concerns about the safety and tolerability of the JAK inhibitor class. The data also showed increased efficacy, and both the safety and efficacy could support the longer-term use that will be needed in vitiligo.

Incyte is presenting the one-year data from the TRuE-V clinical trial program at the American Academy of Dermatology annual meeting, taking place 25-29 March

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