Neuron23 Inc. aims to take two small molecule drug candidates for neurological diseases into the clinic during the next two years, with $100m from a series C venture capital round that the company announced on 30 March. The first clinical trial for lead drug candidate NEU-723, a brain-penetrant leucine-rich repeat kinase 2 (LRRK2) inhibitor for the treatment of select Parkinson’s disease patients, will begin before the end of 2022.
South San Francisco-based Neuron23 is pairing human genetic data with artificial intelligence-enabled drug discovery and biomarker platforms to develop precision medicines for genetically-defined neurological and immunological diseases. NEU-723 will be tested in patients with LRRK2 gene mutations and in others who have LRRK2-driven Parkinson’s disease as determined by a company-developed companion diagnostic
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