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Kite’s Yescarta Is First CAR-T To Move Into Second-Line Lymphoma

 
• By Joseph Haas

Kite beats BMS’s Breyanzi to the first CAR-T approval in second-line large B-cell lymphoma. The added indication could nearly double the number of potential US patients for Yescarta.

Cancer cell therapy
Kite obtains first second-line cancer indication for a CAR-T therapeutic • Source: Alamy

The addition of a new indication for second-line treatment of large B-cell lymphoma for Kite Pharma, Inc.’s Yescarta (axicabtagene ciloleucel) is expected to nearly double the number of US LBCL patients eligible for therapy with the chimeric antigen receptor T-cell (CAR-T), according to the Gilead Sciences, Inc. subsidiary.

Yescarta was cleared for the relapsed or refractory LBCL indication on 1 April, making it the first CAR-T agent to...

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