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Protagonist Weaves Positive Story From Mixed Phase II Data In Ulcerative Colitis

 
• By Jessica Merrill

The company is pushing ahead into Phase III development with the lower dose of an oral drug for ulcerative colitis, even though a Phase II study missed the primary endpoint.

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Investors weren't sure what to make of Phase II data from Protagonist • Source: Alamy

Protagonist Therapeutics, Inc. sees a big potential commercial opportunity for its oral gut-restricted α4β7-integrin antagonist PN-943 in ulcerative colitis (UC) and is pushing ahead with the Phase III development of a low dose formula, despite mixed Phase II data that underwhelmed investors.

The Phase II IDEAL study, evaluating PN-943 at two doses twice a day (450 mg and 150 mg) in patients...

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