Precision’s Allo CAR-T Inches Closer To Filling Post-Auto CAR-T Niche

The company provided Phase I/IIa data for allogeneic CAR-T PBCAR0191 showing a high response rate and signs of durability in aggressive NHL patients relapsing after autologous CAR-T.

Precision BioSciences announced Phase I/IIa data for its allogeneic CAR-T therapy • Source: Shutterstock

Precision BioSciences, Inc. has taken an additional step toward carving out a role for its off-the-shelf CAR-T PBCAR0191 as a treatment option for people who have relapsed after receiving autologous CAR-T with data showing a high response rate and durability in that population.

The company announced 8 June Phase I/IIa data for the allogeneic CAR-T cell therapy candidate in 11 evaluable patients with aggressive non-Hodgkin’s lymphoma (NHL) whose disease had relapsed after receiving autologous CAR-T and who were heavily

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