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Genexine Advances DNA Vaccine With Mid-Stage Cervical Cancer Success

In Regimen With Keytruda

 
• By Ayisha Sharma

The Korean firm’s DNA vaccine has shown promise in a Phase II cervical cancer trial in combination with Merck’s Keytruda, prompting the firm to tout potential in the difficult PD-1 negative group.  

The doctor holds an ampoule with a vaccine. Hand in medical glove. Concept of danger or need for vaccination.
DNA Vaccines Work Similarly To The Better Known mRNA Vaccines • Source: Shutterstock

Genexine Inc.’s first-in-class DNA therapeutic vaccine candidate for HPV-related cancers, GX-188E, has impressed in a challenging cohort of cervical cancer patients in combination with Merck & Co., Inc.’s Keytruda (pembrolizumab) in a mid-stage study.

The Phase II trial enrolled 60 people with advanced HPV 16 – or 18- positive cervical cancer who had progressed after standard-of-care treatment

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