Kalvista Stops Phase II HAE Prophylactic Trial Following Liver Enzyme Concerns

But On-Demand Asset On Track

The US firm’s oral plasma kallikrein inhibitor was associated with liver elevations in a number of Phase II patients, prompting a trial termination and shift in focus to an on-demand program.   

Mature woman doing thyroid self examination on light background, closeup
Hereditary Angioedema Can Cause Potentially Fatal Swelling Of The Airways • Source: Shutterstock

KalVista Pharmaceuticals Inc has terminated a mid-stage trial of its prophylactic drug candidate for hereditary angioedema (HAE) following safety issues but is holding out hope for a more advanced on-demand program for the rare disease.

The US firm said it had terminated the Phase II KOMPLETE trial of KVD824 for the prevention of HAE attacks because multiple treated participants experienced liver enzyme elevations, although importantly

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