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Early Data For Bicycle’s Nectin-4 Asset Shows Promising Duration In Urothelial Cancer

Analysts Cautiously Optimistic

 
• By Ayisha Sharma

The UK-headquartered biotech’s peptide-toxin conjugate showed a prolonged duration of response in advanced urothelial cancer patients in an early-stage trial compared with current standard of care, raising hopes for a differentiated profile.  

Image split into two with red ground on one side and cream-colored ground on the other, one person on each side, representing differentiation
Bicycle's Candidate Is Showing Early Signs Of Differentiation • Source: Shutterstock

Bicycle Therapeutics, plc’s updated Phase I/II data of BT8009 in urothelial cancer have shown potential for improved drug durability and tolerability when compared to Seagen Inc. /Astellas Pharma, Inc.’s standard-of-care Padcev, rousing optimism for the firm’s unique approach.

BT8009 is a bicyclic peptide-toxin conjugate candidate that targets Nectin-4, a cell adhesion molecule that is overexpressed in tumor cells and plays a role in their growth and proliferation. It...

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