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Japan Zolbetuximab Filing Heats Up CLDN18.2 Competition

US, EU, China Filings Also Expected

 
• By Lisa Takagi

Astellas says its first approval filing globally for zolbetuximab - in Japan for gastric cancer - came faster than expected, as Scrip takes a look at the latest status of other CLDN18.2-targeting candidates in late clinical trials.

As Zolbetuximab reaches for approval, it awaits fierce competition for CLDN18.2-targeting drugs.
With first filing, zolbetuximab appears to be leading leading fierce global competition for CLDN18.2-targeting drugs. • Source: Shutterstock

The fierce competition globally around Claudin (CLDN) 18.2-targeting cancer drugs has entered the next phase with Astellas Pharma, Inc.'s first approval filing globally for its first-in-class antibody zolbetuximab, in Japan for CLDN 18.2-positive gastric cancer on 9 June.

Any successful approval, which may come within 12 months assuming standard review timelines in the country, could mark the

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