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Eisai’s Alzheimer’s Pipeline Offers Combination Therapy Potential

Latest Leqembi Analyses Show Consistent Efficacy

 
• By Mandy Jackson

Eisai is testing its anti-tau antibody in combination with the anti-amyloid therapy Leqembi, and earlier-stage programs targeting TrkA, EphA4 and TREM2 offer new approaches and combo potential.

Human brain research and memory loss as symbol of alzheimer's concept with missing pieces of the puzzle
Eisai continues to look for novel mechanisms to treat Alzheimer's disease • Source: Shutterstock

Eisai Co., Ltd. has a challenging task ahead in bringing its Biogen, Inc.-partnered amyloid protofibril-clearing antibody Leqembi (lecanemab) to Alzheimer’s patients in a market that is struggling to meet the testing and I.V. administration requirements for the medicine. However, that hasn’t stopped the company from investing in additional new medicines for the disease, including an anti-tau antibody and other novel treatments that could see use alone or in combination with Leqembi or other drugs.

Eisai continues to analyze results from the Phase III Clarity AD clinical trial that supported full approval by the US...

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