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Verve’s Cholesterol Gene Editing Hits Milestone – With Lilly Now Onboard

 
• By Andrew McConaghie

The gene-editing company has achieved proof-of-concept for its base-editing platform in three patients – but safety concerns have sent its share price into decline.

Verve Therapeutics

Verve Therapeutics's cholesterol lowering candidate, VERVE-101, has shown strong efficacy in its first Phase I study, representing a valuable proof-of-concept for its in vivo gene editing platform.

Investor fears about a handful of adverse events in the small study of 10 participants took some of shine off the results, but analysts nevertheless believe the data are a strong start, especially with Eli

Key Takeaways

  • The initial VERVE-101 results show efficacy similar to existing PCSK9 inhibitors – but could represent a ‘one-and-done’ treatment

  • Analysts were impressed by the results, but the company’s share price has slid after concerns about adverse events on the study

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