Following their toplining in June, the keenly awaited full results of the pivotal HELIOS-B trial of Alnylam Pharmaceuticals Inc.’s Amvuttra in transthyretin amyloidosis with cardiomyopathy (ATTR-CM) have turned out to be something of a disappointment.
Key Takeaways
- Full data from the HELIOS-B trial of Alnylam’s Amvuttra in transthyretin amyloidosis with cardiomyopathy look weaker than data on Pfizer’s Vyndamax and BridgeBio’s acoramidis.
- Amvuttra took longer to have an effect on patients’ mortality than the rival drugs
The data, presented at the annual congress of the European Society of Cardiology in London on 30 August, suggest that Amvuttra (vutrisiran) may be unable to emerge from the shadow of
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