1. Scrip

Lyell Will Seek To Improve On Existing CAR-Ts Via Merger With ImmPACT

 
• By Joseph Haas

Lyell believes ImmPACT’s dual CD19/20-targeted CAR-T could offer better response rates than Yescarta or Breyanzi and will focus on IMPT-314 while terminating much of its own pipeline.

(Shutterstock)

Despite significant fundraising results to date, Lyell Immunopharma has been stuck in neutral with its own cancer cell therapy efforts, and the firm revealed on 24 October that it is merging with privately held ImmPACT Bio, bringing that company’s Phase I chimeric antigen receptor T-cell (CAR-T) therapy candidate into its pipeline and shuttering some of its own existing R&D candidates. Among other changes, Lyell is ceasing its efforts in tumor-infiltrating lymphocyte (TIL) therapies.

Key Takeaways
  • Lyell will pay $30m up front plus a sizeable equity stake to acquire ImmPACT Bio and its Phase I dual anti-CD19/20 CAR-T therapy for B-cell...

On a same-day investor call, Lyell CEO Lynn Sealy said ImmPACT’s lead candidate, the dual-targeting CD19/20-directed CAR-T candidate IMPT-314, may offer better and more durable response rates than existing CD19-directed...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Cell Therapies

More from Therapy Areas

New Vaccine Framework Avoided Worst-Case Scenario, Analysts Say

 
• By Joseph Haas

The new US FDA vaccine guidelines introduced on 20 May might cause financial woes for Moderna, but overall vaccine makers should not be as impacted as feared.

Merck KGaA Plans Phase III For Enpatoran After Mixed Phase II Lupus Data

 
• By Jessica Merrill

The Phase II study testing the novel TLR7/8 inhibitor met the primary endpoint in a cohort of patients with cutaneous lupus erythematosus and systemic lupus erythematosus with rash, but did not in patients with SLE.

PureTech’s IPF Candidate Ready For Phase III After Efficacy Win

 
• By Andrew McConaghie

Coming one day after Boehringer’s underwhelming data, PureTech’s tweaked molecule, deupirfenidone, shows promise in slowing idiopathic pulmonary fibrosis.