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Metsera’s Amylin Analog Stars In Obesity Phase I

 
• By Joseph Haas

Intended as obesity monotherapy and for combination with the firm’s GLP-1 analog, MET-0233i showed best-in-class efficacy with placebo-like tolerability at low doses.

Young woman standing on scales at home. Weight loss concept
Metsera adds promising early data with amylin analog to its GLP-1 candidate • Source: Shutterstock

Already riding high with positive early data for its long-acting GLP-1 analog candidate MET-097i, Metsera grabbed attention again on June 9 with Phase I data for its amylin analog MET-233i, which produced 8.4% weight loss at five weeks with a clean safety profile and pharmacokinetics suitable for monthly dosing. The New York-based firm said it will advance MET-233i as monotherapy for obesity and in combination therapy with MET-097i.

The study included single- and multiple-ascending dose cohorts, with the largest dose tested, a weekly 1.2mg subcutaneous injection, yielding an...

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