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ASH: How Should BCMA-Directed Bispecifics Fit Into Myeloma Treatment?

 
• By Alaric DeArment

With two products on the market, a third on the way and a fourth under development too, the question becomes how they will fit in relative to each other and also CAR-T cell therapies.

(Alaric DeArment/Scrip)

The latest data and expert opinions on BCMA-directed bispecific antibodies for multiple myeloma – including Johnson & Johnson’s Tecvayli (teclistamab-cqyv) and Pfizer’s Elrexfio (elranatamab-bcmm), which have US Food and Drug Administration approval, and Regeneron Pharmaceuticals’ linvoseltamab, which is pending at the FDA – are sparking discussions about how they will fit into the market relative to each other and relative to CAR-T cell therapies.

All three bispecifics were the subject of presentations at the American Society of Hematology annual meeting, which took place in...

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