CSPC’s Global-First Monospecific ADC Promising In Advanced NSCLC

But Biokin Hot On Heels With Bispecific

CSPC’s SYS6010, the first monospecific EGFR-targeting antibody-drug conjugate in the clinic for advanced NSCLC, has shown Phase I promise, but could face close competition with another China-originated bispecific.

Two assets are ready to compete
CSPC's EGFR-targeting ADC SYS6010 showed favorable efficacy in Phase I, especially in patients with EGFR-mutant NSCLC who were resistant to previous EGFR-TKI treatments. (Shutterstock)

Chinese firm CSPC Pharmaceutical has presented promising Phase I results for its first-in-class antibody-drug conjugate (ADC) SYS6010 in non-small cell lung cancer (NSCLC), but the contender is facing close competition from another domestic company.

The therapy conjugates an EGFR antibody with the topoisomerase I inhibitor JS-1 and is the first monospecific EGFR-targeting ADC to progress to the clinical stage in the NSCLC setting, including...

CSPC presented the advanced solid tumor results at the American Association for Cancer Research (AACR) annual meeting in Chicago on 27 April.

Xu Hu

Read more by Xu Hu

Xu is a senior reporter and covers aspects on policy and regulations in China pharma industry within the APAC Pharma news team.

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