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CSPC’s Global-First Monospecific ADC Promising In Advanced NSCLC

But Biokin Hot On Heels With Bispecific

 
• By Xu Hu

CSPC’s SYS6010, the first monospecific EGFR-targeting antibody-drug conjugate in the clinic for advanced NSCLC, has shown Phase I promise, but could face close competition with another China-originated bispecific.

Two assets are ready to compete
CSPC's EGFR-targeting ADC SYS6010 showed favorable efficacy in Phase I, especially in patients with EGFR-mutant NSCLC who were resistant to previous EGFR-TKI treatments. (Shutterstock)

Chinese firm CSPC Pharmaceutical has presented promising Phase I results for its first-in-class antibody-drug conjugate (ADC) SYS6010 in non-small cell lung cancer (NSCLC), but the contender is facing close competition from another domestic company.

The therapy conjugates an EGFR antibody with the topoisomerase I inhibitor JS-1 and is the first monospecific EGFR-targeting ADC to...

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Xu Hu

Read more by Xu Hu

Xu is a senior reporter and covers aspects on policy and regulations in China pharma industry within the APAC Pharma news team.

More from China

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• By Xu Hu

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Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
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AstraZeneca Taps Into China’s R&D Engine With CSPC Alliance

 
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After in-licensing a cardiovascular candidate last year, AstraZeneca has signed a strategic drug discovery alliance, which could generate billions of dollars in payments to the Chinese firm.

Chinese Biotech VC/PE Fundings Rise But Still Modest

 
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More from Therapy Areas

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• By Andrew McConaghie

Open-label extension data have persuaded Roche to move prasinezumab into Phase III, where it believes a few tweaks to the study design could turn a near miss into success.

Quick Listen: Scrip’s Five Must-Know Things

 
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UroGen Gets A First-Ever Bladder Cancer Approval Despite US FDA AdComm ‘No’ Vote

 
• By Joseph Haas

UroGen’s Zusduri was approved despite an advisory committee vote recommending against it in May. It is the first approved drug for a type of recurring bladder cancer.