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Immutep’s LAG-3 Adds To Keytruda In First-Line Lung Cancer

 
• By Elizabeth Cairns

Dosing eftilagimod alpha on top of Merck & Co’s blockbuster appears to improve survival, though more robust data are needed.

Paper lungs with a hole on one side, depicting lung cancer, on blue background

Immutep’s eftilagimod alpha has not so much beaten Keytruda as joined it. An investigator-initiated study has shown that addition of the LAG-3 immunotherapy to the standard-of-care first-line non-small cell lung cancer regimen of Merck & Co’s checkpoint inhibitor plus chemo improved survival by around 10 months.

Key Takeaways
  • An open-label academic trial of Immutep’s eftilagimod alpha plus Merck & Co’s Keytruda and chemo in first-line non-small cell lung cancer shows overall survival 10...

The data are good in themselves but are also important since they derisk Immutep’s own pivotal TACTI-004 trial, which has a very similar design and is about to start. The...

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