Sling Brings Potential Oral Competition To Amgen’s Tepezza In TED

With positive Phase IIb/III data for IGF-1r inhibitor linsitinib, privately held Sling plans to move into Phase III and compete in thyroid eye disease on convenience and safety.

Older eye
Sling is looking to join the competition with Amgen in thyroid eye disease • Source: Shutterstock

Potential competitors to Amgen’s Tepezza (teprotumumab), the only approved drug therapy for thyroid eye disease (TED), keep lining up as privately held Sling Therapeutics unveiled positive Phase IIb/III on 14 January data for linsitinib, an oral insulin-like growth factor-1 receptor (IGF-1R) inhibitor that could provide a convenience advantage in a space where the standard of care and several developmental competitors are injectable.

Key Takeaways
  • Sling Therapeutics is the third company in a month to report positive data in thyroid eye disease, as multiple companies look to take on Amgen...

Based in Ann Arbor, MI, Sling reported topline data from the placebo-controlled LIDS study in 90 patients with active moderate-to-severe TED showing that linsitinib 150mg twice-daily met the primary endpoint...

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