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What Was Behind CervoMed’s Lewy Body Disappointment?

Shares in the CNS disease-focused biotech crashed by nearly 80% after its lead product, neflamapimodin, failed in a Phase IIb study in Lewy body dementia. Investors are pondering what went wrong.

Parkinson's disease. 3D illustration showing neurons containing Lewy bodies small red spheres which are deposits of proteins accumulated in brain cells that cause their progressive degeneration - Illustration
Lewy Bodies • Source: Shutterstock

The failure of CervoMed’s much-anticipated RewinD-LB Phase IIb study of neflamapimodin in patients with dementia with Lewy bodies (DLB) has left investors disappointed and the company scratching its head.

Topline data show the product, CervoMed’s lead candidate, missed the primary endpoint of change in the clinical dementia rating sum of boxes and all of the trial’s key secondary goals.

Key Takeaways

CervoMed's lead product has unexpectedly failed in a Phase IIb study in Lewy body dementia.

The reasons for the failure are not clear,...

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