YolTech Therapeutics, a Shanghai-based start-up focusing on in vivo gene editing, recently announced the initiation of an early Phase I trial with YOLT-204, a first-in-class therapy, in transfusion dependent β-thalassemia (TDT).
YolTech Kicks Off First-In-Class In Vivo Gene Editing Trial For TDT
Other Chinese Firms Build Presence In Field
YolTech’s early clinical stage in vivo gene editing therapy YOLT-204 may provide off-the-shelf treatment in transfusion dependent β-thalassemia without conditioning chemotherapy and HSCT.

More from Clinical Trials
The UK giant is forecasting peak sales of $5bn plus
Novo’s semaglutide has shown its benefits as an injectable in patients with peripheral arterial disease and as an oral agent in cardiovascular outcomes, but stronger results are expected soon from Lilly’s tirzepatide.
Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.
RemeGen is planning to complete enrolment in the global Phase III RemeMG study with telitacicept in generalized myasthenia gravis by the end of 2025 or early 2026. The Chinese firm has already sidelined two other global Phase III trials with the molecule to prioritize the indication.