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Start-Up Previews (05/2010)

A preview of the emerging health care companies profiled in the current issue of Start-Up. "As Drug-Resistant Microbes Rise, Antibiotic Start-Ups Need Savvy Investors," features profiles of Cempra Pharmaceuticals, DesignMedix, Kenta Biotech and MGB Biopharmaceuticals. Plus these Start-Ups Across Health Care: CardioPhotonics, Eureka Genomics, Invuity and OrthoSensor.

Formed around a library of macrolide analogs licensed from Optimer Pharmaceuticals, Cempra Inc.'s Also see "Cempra Pharmaceuticals Inc." - Scrip, 1 May, 2010. original intent was to build an improved version of Ketek, the ketolide antibiotic telithromycin that caused liver toxicity problems after its 2004 US launch. Cempra says its lead candidate CEM-101 is two-to-four times more potent than telithromycin. In addition to an oral form, Cempra is also developing an intravenous version that could be used to treat serious infections in the hospital.

One of the key ways pathogens survive in patients receiving drug therapy for infection is by physically ridding their cells...

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