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Frontiers in Breast Cancer Research, Part II: Developments in Partial Breast Irradiation and Tumor Ablation

As the use of breast conserving lumpectomy expands as a treatment for early-stage breast cancer, interest has surged in alternatives to whole breast irradiation. Follow-on radiation treatment is crucial to the success of this therapy, but a significant number of women are either unable or unwilling to undergo the typical treatment course involving five to seven weeks of daily radiation therapy. The device industry is responding with technologies aimed at delivering post-lumpectomy radiation therapy in a more convenient, potentially safer way.

by Mary Thompson and Kristina Rebelo

As the use of breast conserving lumpectomy expands as a treatment for early-stage breast cancer, so has interest surged in alternatives to whole breast irradiation (WBI), used following breast conserving surgery to reduce the risk of cancer recurrence. Lumpectomy followed by WBI has proven to be just as effective (in terms of cancer recurrence rates) as mastectomy for patients with cancer localized to the breast, and a growing number of patients with early-stage breast cancer are now being offered this treatment option. But follow-on radiation treatment is crucial to the success of this therapy—recurrence rates after lumpectomy are significantly higher when patients do not receive follow-up radiation therapy (39.2% vs 14

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