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MYSTIC Misses: Devastation For AstraZeneca As Imfinzi Fails PFS Endpoint In NSCLC

 
• By Lucie Ellis-Taitt

Topline Phase III data for AstraZeneca's PD-L1 inhibitor Imfinzi in NSCLC have overshadowed the group's second quarter earnings – but not in a good way. Positive Tagrisso data from the Phase III FLAURA trial reported at the same time were not enough to stem the stock bleed.

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AstraZeneca's Imfinzi misses PFS target in MYSTIC trial • Source: Shutterstock

AstraZeneca PLC's PD-L1 inhibitor, Imfinzi (durvalumab), a drug expected to act as the big pharma's backbone drug across its cancer immunotherapy portfolio, has failed to meet primary progression free survival (PFS) endpoints in the Phase III MYSTIC trial in non-small cell lung cancer.

In the Phase III study Imfinzi, a program death-ligand 1 inhibitor, in combination with tremelimumab failed to improve PFS compared...

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CEO Underlines AstraZeneca’s Increasingly US-Centric Growth Plans

 
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Its multibillion dollar investment demonstrates the importance of the US to AstraZeneca, with half of its targeted $80bn revenues by 2030 set to come from the country, Pascal Soriot said as it presented strong second-quarter results.

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Celcuity Preps For Potentially Huge Market After Phase III Gedatolisib Win

 
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The biotech announced positive results in the PIK3CA wild-type population in second-line HR+/HER2- breast cancer for its PAM inhibitor.