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No Advantage For Medtronic’s InFuse Versus Bone Graft In Spine Fusion

The long-awaited independent analysis of clinical data on Medtronic’s InFuse recombinant human bone morphogenetic protein-2 (rhBMP-2) found no advantages to using it as a substitute for traditional bone grafts in spinal fusion surgery, while also revealing that the risks of rhBMP-2 may be greater than has been previously reported.

The initial published clinical reports on Medtronic PLC’s InFuse as a substitute for bone grafts in spinal fusion surgery understated the risks of the recombinant human bone morphogenetic protein-2 (rhBMP-2) relative to its benefits, according to two independent reviews of the clinical evidence published last week in the Annals of Internal Medicine.

The conclusions of the two analyses were mixed on the proper role, if any, of InFuse in spinal surgery cases...

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