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Synta’s Newest Phase II Results Could Reshape Ganetespib’s Pivotal Data, But Some Remain Skeptical

 
• By Michael Goodman

Synta provided one-year follow-up data for its Phase IIb/III trial testing ganetespib in NSCLC and revealed some protocol changes which it believes will de-risk the Phase III design. Analysts on the third quarter earnings call by and large bought into the story, but some skepticism remains.

Synta Pharmaceuticals Corp. management are betting that despite a drop-off in efficacy seen in one-year follow-up data for the Phase IIb/III GALAXY-1 trial of its ganetespib in second-line non-small-cell lung cancer, the protocol changes made for its GALAXY-2 trial should deliver positive pivotal results for the heat shock protein 90 (HSP90) inhibitor.

At one-year follow-up, the survival data from GALAXY-1 were not as robust as were reported in a June update, the company announced after presenting data at the World Conference on...

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Global Pandemic Deal Adopted As 124 Countries Say Yes; US Sits Out

 
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