Antibiotic Spring? Regulatory Incentives Spur Activity – And Maybe Medical Advances

Regulatory incentives have been successful at attracting developers to antibiotic R&D, but significant medical advances have stubbornly remained rare. Now the pipeline has produced the first novel antibiotic to receive breakthrough status from US FDA and some Phase III trials are raising the efficacy bar to superiority.

Antibiotic resistant bacteria closeup biofilm

Achaogen Inc.'s plazomicin, which recently became the first novel systemic antibiotic candidate designated a breakthrough therapy by FDA, is at the forefront of what could be a small wave of new antibacterials that offer improvements in efficacy over existing products.

Despite many and varied global efforts to revitalize antibiotics R&D in the face of growing antimicrobial resistance, new antibiotics in the US for the past decade have at best offered incremental advances

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