Janssen’s Esketamine Needs Better Defined REMS, US FDA Panel Says

Advisory committee overwhelmingly endorses approval for patients with treatment-resistant depression but says proposed Risk Evaluation and Mitigation Strategy needs refinement, including clarifying the types of facilities where the drug will be administered.

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A US FDA advisory committee backed the approval of Janssen R&D LLC’s depression drug esketamine but said the parameters of a proposed Risk Evaluation and Mitigation Strategy (REMS) need to be better defined, particularly as to the types of facilities where the drug will be administered.

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